Hypertension of Plaques

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I am happy to offer a scientific Text on the topic of high blood pressure by Plaques (atherosclerosis as a cause for hypertension) in English: High blood pressure as a result of arteriosclerotic Plaques: Pathophysiological correlates and clinical implications Atherosclerosis, which is characterized walls due to the formation of Plaques in the vessel, it represents one of the major causes of secondary high blood pressure (hypertension). This review article examines the pathophysiological mechanisms by which atherosclerotic changes in the blood pressure increase, and the resulting clinical consequences. Pathogenesis of Plaque formation Atherosclerosis begins with damage to the endothelial cells of the arteries, which leads to a decreased production of vasodilating substances such as nitric oxide (NO). In consequence of lipids, particularly low‑collect-density lipoproteins (LDL) in the Intima of the vessels. These oxidize and trigger an inflammatory reaction in macrophages penetrate into the tissue and develop into foam cells. An oily dispersion that develops over time to a stable or unstable Plaque is formed. Mechanisms of blood pressure increase Plaques lead to more Due to increased blood pressure: Vessel narrowing (stenosis): Due to the narrowing of the vessel lumen increases the peripheral resistance, which can increase the systolic and diastolic blood pressure. This is especially critical in the case of renal artery stenosis, the Renin‑Angiotensin‑aldosterone‑trigger activation (renal hypertension). Reduced vascular elasticity: The deposits of calcium and fibrous tissue make the arteries more rigid. A reduced Compliance of the large arteries leads to an increase in the pulsatile pressure and an increase in the systolic blood pressure, especially in the advanced age. Endothelial dysfunction: A damaged endothelium produces less NO and more vasoconstrictor substances (e.g., Endothelin‑1), which leads to a lasting vasoconstriction and, thus, to an increased peripheral resistance. Inflammatory processes: Chronic inflammation associated with Plaque formation, can interfere with the vascular regulation and to increase blood pressure and contribute. Clinical impact and diagnosis Patients with atherosclerotic Plaques and hypertension have a significantly increased risk for cardiovascular events, including myocardial infarction, stroke, and kidney failure. The diagnostics includes: Measurement of blood pressure over 24 hours (Ambulatory blood pressure monitoring), Ultrasound examination of the carotid and renal arteries and for the detection of Plaques, The determination of LDL‑cholesterol, C‑reactive Protein (CRP) and other risk markers, optionally angiography for accurate localization of stenoses. Therapeutic Strategies An effective treatment must address both the high blood pressure as well as the atherosclerotic disease: Blood pressure lowering drugs: ACE inhibitors or AT1‑receptor blockers (e.g., Losartan) are particularly suitable, since they inhibit in addition to the blood pressure, the Renin‑Angiotensin‑aldosterone axis and a nephro-protective effect. Lipid-lowering drugs: statins (e.g., Atorvastatin) lower the LDL level and stabilize Plaques. Anti‑platelet therapy: acetylsalicylic acid (Asa) reduces the risk of thrombus formation at the plaque surface. Life style modifications: avoidance of Smoking, healthy diet (e.g., DASH diet), regular physical activity, and weight reduction. Summary High blood pressure, which is caused by atherosclerotic Plaques, is a multifactorial process that is based on vasoconstriction, decreased elasticity and endothelial dysfunction. Early diagnosis and a combined therapeutic approach are essential to prevent cardiovascular complications and improve the quality of life of patients in the long term. If you want, I can make certain sections in more detail, or other aspects (e.g., epidemiological data, the molecular mechanisms) complete!

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Hypertension of Plaques

Cardiovascular disease in old age: A growing challenge With increasing age increases the risk of developing cardiovascular diseases. These diseases are among the most common causes of death worldwide, and older people are particularly exposed. Why is this so, and what can you do to lower your risk? The causes: What happens in the body? With the years, to change the blood vessels and the heart itself: The arteries lose elasticity, it deposits (atherosclerosis) are formed, and the blood pressure rises often. These processes are often slow and insidious in front of you — many of the complaints are first hardly noticed. Typical diseases in later life are: Coronary heart disease (CHD): caused By calcification of the coronary arteries, the blood supply to the heart muscle is affected. Congestive heart failure: The heart loses its Capacity and is no longer able to provide the body with sufficient oxygen. High blood pressure (hypertension): A permanently high blood pressure strains the heart and blood vessels. Arrhythmias: disturbances of the heart rhythm, such as atrial fibrillation, can occur in older people more often. Risk factors: What makes the heart grow old? Not only the biological aging plays a role. Many risk factors can affect: unhealthy diets (excessive salt, fat, sugar), lack of physical activity, Overweight and obesity, Smoking and excessive alcohol consumption, chronic Stress, Diabetes mellitus. Prevention: The heart keep fit Dieuch in older age, it is never too late to healthier life habits. The good news: Simple measures can reduce the risk significantly: Regular Exercise. Walks, Swimming, Nordic Walking, strengthen the cardiovascular System and keep the blood vessels elastic. Balanced Diet. More vegetables, fruits, whole grains and low-fat dairy products, less processed foods. Blood pressure and cholesterol control. Regular medical check-UPS allow early detection of problems. On the weight. A healthy body weight relieves the heart and circulation. Do not smoke. The Quit Smoking improves blood circulation and reduces the risk of heart attacks. Stress management. Relaxation techniques such as Meditation or Yoga can help lower blood pressure. Conclusion Cardiovascular diseases are the ages of the major health risks, but they are not inevitable. By a conscious lifestyle and regular checkups, everyone can make a major contribution to the healthy attitude of his heart. It is true: prevention starts today — even in old age.

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Hypertension of Plaques. Pulse in diseases of the cardiovascular System.